Curriculum Vitae, Arthur D. Lander

Publications (as of 12/07)

Lander, A.D., D.K. Fujii, D. Gospodarowicz and L.F. Reichardt, (1982).Characterization of a factor that promotes neurite outgrowth: evidence linking activity to a heparan sulfate proteoglycan. J. Cell Biol. 94, 574-585.

Lander, A.D., Tomaselli, K., Calof, A.L. and Reichardt, L.F., (1983). Studies on extracellular matrix components that promote neurite outgrowth. Cold Spring Harbor Symp. Quant. Biology XLVIII, 661-623.

Reichardt, L.F., W.D. Matthew, A.D. Lander, K. Tomaselli, R. Greenspan, and Greif, K., (1984). Applications of monoclonal antibodies to studies on neurite growth and synapse formation. In Neuroimmunology, P. Behan and F. Spreafico, Editors. Raven Press, New York.

Matthew, W.D., R.J. Greenspan, A.D. Lander, and L.F. Reichardt, (1985). Immunopurification and characterization of a neuronal heparan sulfate proteoglycan. J. Neurosci. 5, 1842-1850.

Lander, A.D., D.K. Fujii, and L.F. Reichardt, (1985). Purification of a factor that promotes neurite outgrowth: isolation of laminin and associated molecules. J. Cell Biol. 101, 898-913.

Lander, A.D., D.K. Fujii, and L.F. Reichardt, (1985). Laminin is associated with the "neurite outgrowth-promoting factors" found in conditioned media. Proc. Natl. Sci. USA 82, 2183-2187.

Lander, A.D. (1987). Molecules that make axons grow. Molecular Neurobiology, 1, 213-245.

Reichardt, L.F., J.L. Bixby, D.E. Hall, M.J. Ignatius, A.D. Lander, Neugebauer, K.M., Tomaselli, K.L. (1988). Glyoproteins that regulate axon growth. In: Molecular Neurobiology: Proceedings of the First NIMH Conference. S. Zalcman and R. Scheller, Eds. U.S. Gov't Printing Office. pp. 110-127.

Lander, A.D. (1989). Understanding the molecules of neural cell contacts: emerging patterns of structure and function. Trends in Neurosciences, 12, 189-195.

Herndon, M.E. and A.D. Lander (1990). A diverse set of developmentally regulated proteoglycans is expressed in rat central nervous system. Neuron 4, 949-961.

Lander, A.D. (1990) Mechanisms by which molecules guide axons. Curr. Opinions Cell Biol., 2, 907-913.

Lee, M.K., and A.D. Lander (1991). Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach. Proc. Natl. Acad. Sci., 88, 2768-2772.

Lim, W., R. Sauer, and A.D. Lander (1991). Analysis of DNA-protein interactions by affinity co-electrophoresis. Methods in Enzymol. 208,196-210.

Birgbauer, E., J.H. Dinsmore, A.D. Lander and F. Solomon (1991). Association of ezrin isoforms with the neuronal cytoskeleton. J. Neurosci. Res. 30, 232-241.

Calof, A.L. and A.D. Lander (1991). Relationship between neuronal migration and cell-substratum adhesion: Laminin and merosin promote olfactory neuron migration but are anti-adhesive. J. Cell Biol. 115, 779-794.

Sanderson, R.D., T.B. Sneed, L.A. Maes, G.S. Sullivan and A.D. Lander (1991). Adhesion of B lymphoid (MPC-11) cells to type I collagen is mediated by the integral membrane proteoglycan, syndecan. J. Immunol. 148, 3902-3911.

Calof, A.L., A.D. Lander and D.M. Chikaraishi (1991). Regulation of neurogenesis and neuronal differentiation in primary and immortalized cells from mouse olfactory epithelium. In Regeneration of Vertebrate Sensory Receptor Cells. Wiley, Chichester (Ciba Foundation Symposium 160). pp. 249-276.

San Antonio, J.D., A.D. Lander, T.C. Wright, and M.J. Karnovsky (1992). Heparin inhibits the attachment and growth of Balb/c-3T3 fibroblasts on collagenous substrata. J. Cell. Physiol. 150, 8-16.

Hynes, R.O. and A.D. Lander, (1992) Contact and adhesive specificties in the associations, migrations and targetting of cells and axons. Cell 68, 303-322.

San Antonio, J.D., J. Slover, J. Lawler, M.J. Karnovsky and A.D. Lander (1993). Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin. Biochemistry, 32, 4746-4755.

Lander, A.D. (1993). Proteoglycans. In: Guidebook to the Extracellular Matrix and Adhesion Proteins. T. Kreis and R. Vale, Eds. Oxford Univ. Press, pp. 12-16.

Lander, A.D. and A.L. Calof (1993). Extracellular matrix in the developing nervous system. In: Molecular Genetics of Nervous System Tumors, A.J. Levine and H.H. Schmidek, Eds., Wiley-Liss, New York. pp. 341-355.

Lander, A.D. (1993). Proteoglycans in the nervous system. Curr. Opinions Neurobiol. 3, 716-723.

Stipp, C.S., E.D. Litwack and A.D. Lander (1994). Cerebrogylcan: An integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. J. Cell Biol. 124, 149-160.

Litwack, E.D., C.S Stipp and A.D. Lander (1994). Neuronal expression of glypican, a cell-surface glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan, in the adult rat nervous system. J. Neurosci. 14, 3713-3724.

Sanderson, R.D., J. Turnbull, J.T. Gallagher and A.D. Lander (1994). Structure of heparan sulfate regulates proteoglycan function and cell behavior. J. Biol. Chem. 269, 13100-13106.

Witt, D.P. and A.D. Lander (1994). Differential binding of chemokines to glycosaminoglycan subpopulations. Current Biology. 4, 394-400.

San Antonio, J.D., A.D. Lander, M.J. Karnovsky and H.S. Slayter (1994). Mapping the heparin binding sites on type I collagen monomers and fibrils. J. Cell Biol. 125, 1179-1188.

Calof, A.L., M.R. Campanero, J.J. O'Rear, P.D. Yurchenco and A.D. Lander (1994). Domain-specific activation of neuronal migration and neurite outgrowth-promoting activities of laminin. Neuron 13, 117-130.

San Antonio, J.D., M.J. Karnovsky, S. Gay, R.D. Sanderson and A.D. Lander (1994). Interactions of syndecan-1 and heparin with human collagens. Glycobiology 4, 327-332.

Calof, A.L., M.D. Adusumalli, M.K. DeHamer, J.L. Guevara, J.S. Mumm, S.J. Whitehead and A.D. Lander (1994). Generation, differentiation and maturation of olfactory receptor neurons in vitro. In: Olfaction and Taste XI. K. Kurihara, N. Suzuki and H. Ogawa, Eds., Springer Verlag, Tokyo. pp. 36-40.

Emerling, D. and A.D. Lander (1994). Laminar-specific behaviors of thalamic neurons on cultured slices of embryonic cerebral cortex. Development 120, 2811-2822 .

Lander, A.D. (1994). Targeting the glycosaminoglycan-binding sites of proteins. Chemistry and Biology 1, 73-78.

Kindt, R.M. and A.D. Lander (1995). Pertussis toxin inhibits growth cone guidance by a mechanism independent of direct G-protein inactivation. Neuron 15, 79-88.

Magendantz, M., M.D. Henry, A.D. Lander and F. Solomon (1995). Inter-domain interactions of radixin in vitro. J. Biol. Chem. 270, 25324-25327.

Williamson, T.G., S.S. Mok, A. Henry, R. Cappai, A.D. Lander, V. Nurcombe, K. Beyreuther, C.L. Masters and D.H. Small (1996) Glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth. J. Biol. Chem. 271 , 31215-31221.

Emerling, D.E. and A.D. Lander (1996) Inhibitors and promoters of thalamic neuron adhesion and outgrowth in embryonic neocortex: functional association with chondroitin sulfate. Neuron 17, 1089-1100,

Lander, A.D., C.S. Stipp and J.K. Ivins (1996) The Glypican Family of Heparan Sulfate Proteoglycans: Major Cell-Surface Proteoglycans of the Developing Nervous System. Perspectives Devel. Neurobiol. 3, 347-358

Herndon, M.E. and A.D. Lander (1996) Analysis of protein-glycosaminoglycan interactions by affinity co-electrophoresis. In: A Laboratory Guide to Glycoconjugate Analysis. P. Jackson and J.T. Gallagher, Eds., Birkhauser Verlag, Basel. BioMethods, 9, 377-396.

Ivins, J.K., E.D. Litwack, A. Kumbasar, C.S. Stipp and A.D. Lander (1996) Cerebroglycan is a neuronal cell surface heparan sulfate proteoglycan expressed on developing axons and growth cones. Developmental Biology 184, 330-322.

Saunders, S., S. Paine-Saunders, and A.D. Lander (1997) Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb and brain. Developmental Biology, 190, 78-93.

Watson, D.J., A.D. Lander and D.J. Selkoe (1997) Heparin-binding properties of the amyloidogenic peptides A-beta and amylin: dependence on aggregation state and inhibition by Congo red. J. Biol. Chem. 272, 31617-31624.

Litwack, E.D., J.K. Ivins, A. Kumbasar, S.E. Paine-Saunders, C.S. Stipp and A.D. Lander (1998) Expression of the heparan sulfate proteoglycan glypican-1 in the developing rodent. Developmental Dynamics, 211, 72-87.

Hoffman-Kim, D., A.D. Lander and S. Jhaveri (1998) Regional differences in immunostaining for chondroitin sulfate in the developing tectum reflect differential GAG biosynthesis. J. Neurosci., 18, 5881-5890.

Liu, W., E.D. Litwack, A.D. Lander, M.H. Stanley, J.K. Langford and R.D. Sanderson (1998) Heparan sulfate proteoglycans as adhesive and anti-invasive molecules: syndecans and glypican have distinct functions. J. Biol. Chem., 35, 22825-22832.

Ivins, J.K., H Colognato, J. A. Kreidberg, P. D. Yurchenco and A. D. Lander (1998) Neuronal receptors mediating responses to antibody-activated laminin-1. J. Neurosci. 18, 9703-9715

Kleef, J, T. Ishiwata, A. Kumbasar, H. Friess, M.W. Büchler, A.D. Lander and M. Korc (1998) The cell surface heparan sulfate proteoglycan glypican-1 is an essential regulator of growth factor action in pancreatic carcinoma cells, and is overexpressed in human pancreatic cancer. J. Clin. Invest. 102, 1662-1673

Lander, A.D. (1998) Proteoglycans: Master regulators of molecular encounter? Matrix Biology, 17, 465-472.

Lander, A.D. (1999). Proteoglycans. In: Guidebook to the Extracellular Matrix and Adhesion Proteins. 2nd Edition. T. Kreis and R. Vale, Eds. Oxford Univ. Press, pp. 351-356.

Herndon, M.E., C.S. Stipp and A.D. Lander (1999) Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity, and the participation of core proteins in binding. Glycobiology 9, 143-155

Lander, A.D. (1999) Seeking the functions of cell surface heparan sulphate proteoglycans. In Cell Surface Proteoglycans in Signalling and Development (Human Frontiers Science Program Workshop VI), A.D. Lander, H. Nakato, S. Selleck, J. Turnbull, and C. Coath, Eds. HFSP, Strasbourg, pp. 73-87.

Kleef, J., S. Wildi, A. Kumbasar, H. Friess, A.D. Lander and M. Korc (1999) Stable transfection of a glypican-1 antisense construct decreases tumorigenicity in PANC-1 pancreatic carcinoma cells. Pancreas, 19, 281-288.

Wildi, S., J. Kleeff, H. Maruyama, C.A. Maurer, H. Friess, M.W. Büchler, A.D. Lander and M. Korc (1999) Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer. Clinical Cancer Res. 5, 2840-2847.

Lander, A.D. and S. Selleck (2000) The elusive functions of proteoglycans: In vivo veritas. J. Cell Biol. 148, 227-232.

Ivins J.K., P.D. Yurchenco, and A.D. Lander (2000) Regulation of neurite outgrowth by integrin activation. J. Neurosci. 20, 6551-6560.

Emerling D.E., and A.D. Lander (2000) Using organotypic tissue slices as substrata for the culture of dissociated cells. Methods Mol Biol 139, 245-256.

Zhu, Z.-w., H. Friess, L. Wang, M. Abou-Shady, A. Zimmermann, A.D. Lander, M. Korc, J. Kleeff and M. BŸchler (2001) Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders. Gut, 48, 558-564.

Chen, R.L. and A.D. Lander (2001) Mechanisms underlying preferential assembly of heparan sulfate on glypican-1. J. Biol. Chem. 267, 7507-7517.

Karumanchi SA, V Jha , R Ramchandran , A Karihaloo , L Tsiokas , B Chan, M Dhanabal, J-i Hanai, G Venkataraman, Z Shriver, N Keiser, R Kalluri, H Zeng, D Mukhopadhyay, R L Chen, AD Lander, K Hagihara, Y Yamaguchi, R Sasisekharan, L Cantley, and V P. Sukhatme (2001) Cell Surface Glypicans Are Low-Affinity Endostatin Receptors. Molecular Cell 7, 811-822.

San Antonio, J. and A.D. Lander (2001) Affinity coelectrophoresis of proteoglycan-protein complexes. In: Methods in Molecular Biology vol 171: Proteoglycan Protocols, R.V. Iozzo, Ed., Humana Press, Totowa NJ, pp. 401-414.

Matsuda, K., H. Maruyama, F. Guo, J. Kleeff, J. Itakura, Y. Matsumoto, A.D. Lander and M. Korc (2001) Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. Cancer Research, 61,.5562-5569.

Lander, A.D., Q. Nie and F.Y.-M. Wan (2002) Do morphogen gradients arise by diffusion? Developmental Cell 2, 785-796.

Tsai, E.S., S. J. Haraldson, J. Baratta, A.D. Lander, J. Yu and R. T. Robertson (2002) Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation, Neuroscience 115, 815-827.

Murray, R.C., D. Navi, J. Fesenko, A.D. Lander, and A.L. Calof (2003) Widespread defects in the primary olfactory pathway caused by loss of MASH1 function. J. Neurosci. 23, 1769-1780.

Kao, J., Nie, Q., Teng, A., Wan, F., Lander, A. and Marsh, J.L. (2003) Can morphogen activity be enhanced by its inhibitors? Proc of 2nd MIT Conference on Computational Fluid and Solid Mechanics, 2, 1729-1733.

Krantz, I D, J. McCallum, C. DeScipio, M. Kaur, L. A. Gillis, D. Yaeger, L. Jukofsky, N. Wasserman, A. Bottani, C.A. Morris, M.J.M. Nowaczyk, H. Toriello, M.J. Bamshad, J.C. Carey, E. Rappaport, S. Kawauchi, A.D. Lander, A.L. Calof , H-h Li, M. Devot, L.G. Jackson (2004) Cornelia de Lange Syndrome is caused by Mutations in NIPBL, the human homolog of the Drosophila Nipped-B gene. Nature Genetics, 36, 631-635.

Lander, A.D. (2004) A calculus of purpose. PloS Biology 2, 712-714.

Lander, A.D., Q. Nie, and F.Y.M. Wan (2005) Aggregation of a distributed source in morphogen gradient formation. Studies in Applied Mathematics, 114, 343-374.

Lander, A.D., Q. Nie, and F.Y.M. Wan (2005). Spatially distributed morphogen synthesis and morphogen gradient formation. Math Biosci & Eng. 2, 239-262.

Mizutani C.M., Q. Nie, F.Y.M. Wan, Y.-T. Zhang, P. Vilmos, R. Sousa-Neves, E. Bier, J.L. Marsh and A.D. Lander (2005) Formation of the BMP activity gradient in the Drosophila embryo. Developmental Cell. 8, 915-924.

Kim, Joon, H.-H. Wu, A. D. Lander, K. Lyons, M. M. Matzuk, and A. L. Calof (2005) Gdf11 Controls the Timing of Progenitor Cell Competence in Developing Retina. Science 308, 1927-1930.

Xie, F., P.C.-Y. Sheu, A.D. Lander and V. Cristini (2005) Semantic analysis and synthesis of complex biological systems. Intl. J. of Software Engineering and Knowledge Engineering 15, 547-569

Ding, K., M. Lopez-Burks, J. A., S‡nchez-Duran, M. Korc, and A.D. Lander (2005) Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J. Cell Biol. 171, 729-38.

Lander, A.D., Q. Nie and F.Y.M. Wan (2006) Internalization and End Flux in Morphogen Gradient Formation. J. Computat. Appl. Math. 190, 232-251.

Lander, A.D., Q. Nie and F.Y.M. Wan (2006) Membrane associated non-receptors and morphogen gradients. Bulletin of Math Biology. 69, 33-54.

Lander, A.D. (2007) Morpheus Unbound: Re-imagining the Morphogen Gradient. Cell, 128, 245-256.

Zhang, Y.T., A.D. Lander and Q. Nie (2007) Computational analysis of BMP gradients in dorsal-vental patterning of the zebrafish embryo. J. Theor. Biol., 248, 579-589.

White, R.J., Q. Nie, A.D. Lander and T.F. Schilling (2007) Shaping the retinoic acid morphogen gradient in the zebrafish embryo by regulation of degradation. PloS Biology, 5, e304.

Kawauchi, S., R. Santos, M.E. Lopez-Burks, C.M. Young, M.P. Hoang, A. Chua, T. Lao, M.S. Lechner, L. Kitzes, B. Hallgrimsson, A.L. Calof and A.D. Lander (200X) Multiple organ system defects and transcriptional dysregulation in the Nipbl+/- mouse, a model of Cornelia de Lange Syndrome. Submitted

Lander, A.D., F.Y.M. Wan, H. Elledge, C. Mizutani, E. Bier and Q. Nie (200X) Diverse paths to morphogen gradient robustness. In revision.